Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension.

The article explores the role of malic enzyme 1 (ME1) in the development of pulmonary hypertension (PH), a serious condition characterized by increased pressure in the arteries of the lungs. The study found that ME1 was more active in the blood vessels of PH patients and animal models. Inhibiting ME1 improved the function of the blood vessels and reduced PH in mice. This suggests that targeting ME1 could be a potential treatment for PH. The article also references three scientific papers that discuss the use of adenosine receptors in treating pulmonary arterial hypertension and cardiovascular health, providing valuable insights for researchers and medical professionals. [Extracted from the article]