Next-generation vaccines for tropical infectious diseases.

• TAK-003 a recent candidate is a significant advancement to Dengvaxia. • Combination vaccination could have an extraordinary impact on schistosomiasis control. • New concepts on how to rationally design hookworm subunit vaccines. • Typhoid conjugate vaccines will reduce the global burden of typhoid fever. Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases; however, these have been difficult to develop, mostly because of the complex nature of the pathogen lifecycles. Here, we present recently developed vaccine candidates for five tropical infectious diseases in the form of a catalog that have either entered clinical trials or have been licensed for use. We deliberate on recently licensed dengue vaccines, provide evidence why combination vaccination could have a synergistic impact on schistosomiasis, critically appraise the value of typhoid conjugate vaccines, and discuss the potential of vaccines in the efforts to eliminate vivax malaria and hookworms. [ABSTRACT FROM AUTHOR]