Correlation between D. Dimer, ferritin and IL-6 levels in vaccinated people by Pfizer-BioNTech (BNT162b2) or Sinopharm (BBIBP-CorV) COVID-19 vaccine.

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, and it spreads quickly without symptoms sometimes among people and leads to various complications in the body, there is a clear increase in D-dimer and ferritin as a result of this infection, these inflammatory proteins are like a ticking bomb for inflammation by release a lot of inflammatory cytokines like IL-6 that appeared with the cytokine storm in COVID-19 patients, therefore Sinopharm and Pfizer's vaccines are among the most important vaccines used in Iraq to prevent infection, that is why the aim of this study was to know the effect of the Covid-19 vaccines on the immune response by studying some immune markers by collected the Blood from infected and convalescent patients and according to the periods of vaccinations (T0 before vaccination, T1 after 21 days of the first dose, and T2 after 21 days of the second dose) and the three marker tests required for the study (D-dimer, ferritin, and interleukin-6) were performed according to the diagnostic leaflet of each kit. The results showed highly significant differences in infected and convalescent patients when compared with vaccinated subjects with Pfizer or Sinopharm for all three markers and don't show any significant differences in vaccinated subjects with Pfizer or Sinopharm vaccine after the second dose. And the study concluded that the vaccine does not stimulate a harmful inflammatory response, as in the case of infection. [ABSTRACT FROM AUTHOR]