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Association between beta-blocker utilization and heart failure mortality in the peritoneal dialysis population: a cohort study.
- Source :
-
Clinical Kidney Journal . Mar2024, Vol. 17 Issue 3, p1-10. 10p. - Publication Year :
- 2024
-
Abstract
- Background The prognostic significance of beta(β)-blocker therapy in patients at end-stage renal disease, specifically those receiving peritoneal dialysis (PD) and presenting with heart failure, remains inadequately elucidated due to limited research conducted thus far. Methods A retrospective analysis was performed on a cohort comprising 608 patients receiving PD between September 2007 and March 2019, with a subsequent follow-up period extending until December 2020. Cox regression and propensity score matching weighted analysis was used to model adjusted hazard ratios for β-blocker use with heart failure-related mortality. Competing risk analysis and subgroup analysis were carried out to further elucidate the correlation. Results β-blockers were prescribed for 56.1% of the peritoneal dialysis patients. Heart failure occurred in 43.4% of the total population and 15.5% of deaths were due to heart failure. The prescription of β-blockers was associated with a 43% lower adjusted hazard ratio (HR) for heart failure death within the cohort (95% confidence interval [CI] = 0.36–0.89; P  = 0.013). Even after accounting for competing risk events, patients in the group using β-blockers demonstrated a significantly lower cumulative risk of heart failure-related mortality compared to those not using β-blockers (P  = 0.007). This protective effect of β-blockers was also observed in subgroup analyses. Conversely, β-blocker use had no statistically significant associations with all-cause mortality. Conclusion The use of β-blockers was associated with a reduced risk of heart failure-related mortality in the PD population. Future randomized clinical trials are warranted to confirm the beneficial effect of β-blockers in the context of PD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20488505
- Volume :
- 17
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical Kidney Journal
- Publication Type :
- Academic Journal
- Accession number :
- 177084144
- Full Text :
- https://doi.org/10.1093/ckj/sfae022