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Identification of m6A-related lncRNAs LINC02471 and DOCK9-DT as potential biomarkers for thyroid cancer.
- Source :
-
International Immunopharmacology . May2024, Vol. 133, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
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Abstract
- • Prognostic signature of m6A-associated lncRNAs constructed in thyroid cancer. • Prognostic signature correlate with immune infiltration. • Prognostic signature correlates with response to immunotherapy. • LINC02471 and DOCK9-DT as new biomarkers in thyroid cancer. Thyroid cancer (THCA) is the most common endocrine malignancy worldwide and has been rising at the fastest rate in recent years. Long-stranded non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) have been associated with immunotherapy efficacy and cancer prognosis. However, how m6A-associated lncRNAs (mrlncRNAs) affect the prognosis of patients with thyroid cancer is unclear. Therefore, this study utilized The Cancer Genome Atlas (TCGA) database to provide thyroid cancer-related transcriptomic data and related clinical data. The R program was used to identify m6A-related lncRNAs, and a risk model consisting of two lncRNAs (LINC02471 and DOCK9-DT) was obtained using least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Kaplan-Meier survival analysis and transient subject operating characteristics (ROC) were used for analysis. The results showed a substantial association between immune cell infiltration and risk scores. Independent analyses confirmed that the expression of LINC02471 and DOCK9-DT was significantly higher in thyroid cancer tissues than in normal tissues, suggesting that they may be useful biomarkers for thyroid cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THYROID cancer
*TUMOR markers
*LINCRNA
*DISEASE risk factors
*CANCER prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 133
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 177086515
- Full Text :
- https://doi.org/10.1016/j.intimp.2024.112050