康复训练联合高压氧对高血压脑出血术后患者脑血管动力学, 血管内皮功能和血清 NSE, UCH-L1, GFAP 的影响.

Objective: To observe the effects of rehabilitation training combined with hyperbaric oxygen on cerebrovascular dynamics, vascular endothelial function and serum neuron specific enolase (NSE), ubiquitin carboxyl terminal hydrolase (UCH-L1) and glial fibrillary acidic protein (GFAP) in patients with hypertensive cerebral hemorrhage after operation. Methods: 112 patients with hypertensive intracerebral hemorrhage who underwent minimally invasive drilling and drainage surgery at our hospital from March 2021 to December 2022 were divided into a control group (n=56, receiving routine rehabilitation training) and an observation group (n=56, combining hyperbaric oxygen intervention with the control group) according to the random number table method.The scale scores [activities of daily living scale-ｍodified Barthel index(MBI), Fugl-Meyer motor function rating scale (FMA), National Institutes of Health Stroke Scale (NIHSS)], cerebrovascular dynamics indexes [mean blood flow (Qmean), peripheral resistance (R), mean blood flow velocity (Vmean)], vascular endothelial function [endothelin-1 (ET-1), nitric oxide (NO)], serum NSE, UCH-L1, GFAP levels and adverse reactions were compared between two groups. Results: Compared with control group after intervention, the MBI and FMA scores in observation group were higher, and the NIHSS score was lower (P<0.05). Compared with control group after intervention, the Vmean and Qmean in observation group were higher, and the R was lower (P<0.05). Compared with control group after intervention, NSE, UCH-L1 and GFAP in observation group were lower (P<0.05). Compared with control group after intervention, NO was higher and ET-1 was lower in observation group (P<0.05). There was no difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Rehabilitation training combined with hyperbaric oxygen intervention in patients with hypertensive intracerebral hemorrhage after operation, which can effectively improve cerebrovascular dynamics, vascular endothelial function and serum NSE, UCH-L1, GFAP levels, reduce neurological damage, and improve self-care ability. [ABSTRACT FROM AUTHOR]