Deoxyfluorinated amidation and esterification of carboxylic acid by pyridinesulfonyl fluoride.

The article discusses a method for synthesizing amide bonds using deoxyfluorinated carboxylic acids and pyridinesulfonyl fluoride. The authors optimized the reaction conditions and explored the substrate scope, demonstrating the versatility and utility of their method. They also showcase the application of this methodology in the synthesis of a challenging ester-linked compound and a tetrapeptide. The research was supported by various funding sources, and there are no conflicts of interest to declare. This article provides valuable information for researchers in the field of medicinal chemistry and organic synthesis. [Extracted from the article]