Anti Microbial Resistance pattern of Klebsiella species in Tertiary care Hospital.

Introduction: Klebsiella is the primary cause of respiratory tract infection like pneumonia, Rhinoscleromatis, sinusitis and cholecystitis. Klebsiella pneumoniae is primary pathogens and can cause a classic from of primary pneumoniae. Klebsiella pneumonia can also cause urinary tract infection, nosocomial infection, wound infection biliary tract infection, peritonitis, meningitis, bacteremia, enteritis, septicemia. Multidrug-resistant Klebsiella pneumoniae (MDRKP) has become an urgent risk to public health as its prevalence has sharply surged around the globe in recent decades. Therefore, to understand the antibiotic sensitivity pattern of K. pneumoniae from various specimens in West India and to provide a basis for the selection of appropriate antibiotics, this study was investigated. Materials and methods: This study was conducted at Diagnostic Microbiology section of Central laboratory, Dhiraj General Hospital, SBKS MI and RC, Piparia, Vadodara over the period of April 2022 to September 2022. There were various sample should be collected according to site of infection like urine, blood, pus, sputum and other body fluids. Data collection was carried out based on a questionnaire that was previously designed in terms of gender, age, the type of antibiotic. Detection and differentiation of sensitive, semi-sensitive and resistant conditions from each other was performed based on the diameter of the around the colony as millimeters and according to the relevant table in laboratory. The data were collected, recorded and analyzed statistically. Results: At the time study period, total 750 specimens was collected and 114 specimen was positive for Klebsiella isolates from various specimen. Most affected age group were 31-40 years (30), 41-50 years (23), 51-60 years (18). In the present study, out of 117 Klebsiella isolates, 91.87% resistant to Ampicillin, 58% to Amikacin, 88.03% to Cefuroxime, 69% to Ceftazidime, 63% to Cefepime, 86% to Ciprofloxacin, 61% to Imipenem, 62% to Gentamicin, 58% to Cotrimaxazole. Conclusion: We may draw the conclusion that K. pneumoniae antibiotic resistance is a real threat and requires close monitoring to be controlled. This study indicated relatively high prevalence of multidrug resistance Klebsiella species. This data had important implication for the quality of patient care in hospital settings specially in antibiotics selection, infection control practices and need for additional studies. [ABSTRACT FROM AUTHOR]