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A Practical Green Synthesis of (R)-5,7-difluorochroman-4-ol, a Key Intermediate of Tegoprazan.
- Source :
-
Organic Preparations & Procedures International . 2024, Vol. 56 Issue 3, p264-270. 7p. - Publication Year :
- 2024
-
Abstract
- This article discusses the development of an improved and eco-friendly synthesis method for (R)-5,7-difluorochroman-4-ol, a key intermediate in the production of Tegoprazan, a medication used to treat acid-related diseases. The researchers optimized the reaction conditions and achieved a high yield and purity of the desired product using lipase-catalyzed resolution and Mitsunobu inversion. This method shows promise for practical use in the green synthesis of Tegoprazan due to its efficiency and environmental sustainability. The document provides a detailed account of the synthesis process and acknowledges financial support from the CQMU Program for Youth Innovation in Future Medicine. [Extracted from the article]
- Subjects :
- *MOLARITY
*MELTING points
*BUTYL methyl ether
*LIPASES
Subjects
Details
- Language :
- English
- ISSN :
- 00304948
- Volume :
- 56
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Organic Preparations & Procedures International
- Publication Type :
- Academic Journal
- Accession number :
- 177179083
- Full Text :
- https://doi.org/10.1080/00304948.2023.2292445