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Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker.
- Source :
-
Cell & Bioscience . 5/12/2024, Vol. 14 Issue 1, p1-16. 16p. - Publication Year :
- 2024
-
Abstract
- Enolase, a multifunctional protein with diverse isoforms, has generally been recognized for its primary roles in glycolysis and gluconeogenesis. The shift in isoform expression from α-enolase to neuron-specific γ-enolase extends beyond its enzymatic role. Enolase is essential for neuronal survival, differentiation, and the maturation of neurons and glial cells in the central nervous system. Neuron-specific γ-enolase is a critical biomarker for neurodegenerative pathologies and neurological conditions, not only indicating disease but also participating in nerve cell formation and neuroprotection and exhibiting neurotrophic-like properties. These properties are precisely regulated by cysteine peptidase cathepsin X and scaffold protein γ1-syntrophin. Our findings suggest that γ-enolase, specifically its C-terminal part, may offer neuroprotective benefits against neurotoxicity seen in Alzheimer's and Parkinson's disease. Furthermore, although the therapeutic potential of γ-enolase seems promising, the effectiveness of enolase inhibitors is under debate. This paper reviews the research on the roles of γ-enolase in the central nervous system, especially in pathophysiological events and the regulation of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20453701
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cell & Bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 177193496
- Full Text :
- https://doi.org/10.1186/s13578-024-01240-6