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An Improved Shape Annealing Algorithm for the Generation of Coated Deoxyribonucleic Acid Origami Nanostructures.
- Source :
-
Journal of Mechanical Design . May2024, Vol. 146 Issue 5, p1-10. 10p. - Publication Year :
- 2024
-
Abstract
- In recent years, the field of structural DNA nanotechnology has advanced rapidly due to transformative design tools. Although these tools have been revolutionary, they still bear one overall limitation of requiring users to fully conceptualize their designs before designing. Recently, a simple computational casting technique was developed using generative optimization strategies to automate the DNA origami nanostructure design. This approach employs a shape annealing algorithm, which creates a formal language of honeycomb nanostructures with shape grammars and drives designs from the language toward a desired configuration using simulated annealing. This initial demonstration of the approach can generate novel scaffold routing schemes for creating solid or hollow structures constrained by the boundaries of polyhedral meshes. The results from the initial approach, particularly from the hollow structures, reveal a challenging design space. This simple technique generates novel scaffold routing schemes that do not replicate the overall polyhedral mesh shape and are limited in their ability to control scaffold path exploration in the design space. This paper demonstrates an approach for achieving different levels of consistent effective wall thicknesses and improving the quality of mesh coverage for hollow structures that can be tuned and optimized by introducing a more refined computational casting technique. We achieve these improvements through changes in the simulated annealing algorithm by adding a Hustin move set algorithm that dynamically adjusts the performance of the overall design and redefining how these hollow designs are articulated. This work illustrates how the technique can navigate a challenging design space to generate effective hollow designs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10500472
- Volume :
- 146
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Mechanical Design
- Publication Type :
- Academic Journal
- Accession number :
- 177208919
- Full Text :
- https://doi.org/10.1115/1.4064242