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Access to 8-Aminoindolizine Fused with Quinone via Cu(OAc)2 -Catalyzed Domino [4+2] Annulation.

Authors :
Lee, Sunhee
Lee, Yechan
Namkung, Wan
Kim, Ikyon
Source :
Synthesis. Jun2024, Vol. 56 Issue 11, p1799-1806. 8p.
Publication Year :
2024

Abstract

This article discusses the design and synthesis of heterocyclic core scaffolds for drug discovery research. The researchers were able to generate unique heterocyclic skeletons from a common derivative and discovered that an amino moiety could be added to the ring system through annulative reactions with quinones. The target compound possesses both carbonyl and amino groups, similar to biologically active quinones. The researchers optimized the reaction conditions and found that the use of Cu(OAc)2 as a catalyst provided the desired product in high yield. The synthesis of various compounds was also explored. These compounds were tested for their anticancer effects and showed good inhibitory activities against human hepatocellular cells and prostate adenocarcinoma cells. The study suggests that these compounds could be further developed as potential anticancer agents for the treatment of liver and prostate cancer. The given text provides data and information related to the synthesis and characterization of compounds 4a, 4b, 4c, 4d, and 4e. The compounds were synthesized using a general procedure involving the reaction of naphthoquinone with different reagents. The compounds were obtained in good yields and characterized using various techniques such as NMR and HRMS. The data presented in the text can be used by researchers studying the cytotoxic effects of these compounds on HepG2 and PC-3 cells. The document provides information on the synthesis and characterization of various compounds. The compounds are described in terms of their chemical structures [Extracted from the article]

Details

Language :
English
ISSN :
00397881
Volume :
56
Issue :
11
Database :
Academic Search Index
Journal :
Synthesis
Publication Type :
Academic Journal
Accession number :
177222643
Full Text :
https://doi.org/10.1055/a-2259-3283