Remote Enantioselective Epoxidation Reactions Catalyzed by Chiral Iron Porphyrin Complexes with a Hydrogen-Bonding Site.

This document summarizes a study on the use of chiral iron porphyrin complexes as catalysts for remote enantioselective epoxidation reactions. The study found that catalysts with an elongated linker were most effective for olefins that were four carbon atoms away from the lactam binding site. The presence of a hydrogen-bonding interaction between the catalyst and the substrate was also important for achieving high enantioselectivity. However, a high enantioselectivity could only be achieved if the substrate binding offered a kinetic advantage compared to a racemic catalyst. The study provides valuable insights into the factors that influence the enantioselectivity of epoxidation reactions. [Extracted from the article]