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Asymmetric Synthesis of Dihydrospirotryprostatin B via a Silica Gel‐Mediated Cyclization of Tryptamine‐Ynamide.
- Source :
-
Chinese Journal of Chemistry . Jun2024, Vol. 42 Issue 12, p1355-1359. 5p. - Publication Year :
- 2024
-
Abstract
- Comprehensive Summary: An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps (8 purifications) from L‐tryptophan. The main feature of our synthetic strategy is the efficient construction of spirocyclic oxindole intermediate containing a chiral quaternary carbon center, involving the silica gel‐mediated cyclization of tryptamine‐ynamide and oxidation under neat conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASYMMETRIC synthesis
*RING formation (Chemistry)
*SILICA
*OXIDATION
*TRYPTOPHAN
Subjects
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 42
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 177244556
- Full Text :
- https://doi.org/10.1002/cjoc.202300727