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SYNTHESIS, CHARACTERISATION, AND ANTICANCER AND ANTIOXIDANT ACTIVITIES OF NOVEL COMPLEXES OF PALLADIUM AND AN ORGANIC SCHIFF-BASE LIGAND.
- Source :
-
Bulletin of the Chemical Society of Ethiopia . 2024, Vol. 38 Issue 3, p606-613. 9p. - Publication Year :
- 2024
-
Abstract
- Treatment of the Schiff base 2-N-(salicylidene) benzothiazole (SabtH) with palladium chloride afforded the neutral 2-N-(salicylidene) benzothiazole palladium(II) complex. This was then treated with one molar equivalent of either ethylenediamine or 1,10-phenanthroline, yielding the neutral mixed ligand complexes 1 and 2, respectively. The prepared organic ligand and its mixed ligand complexes were characterised via UV-Vis, FTIR, ¹H-NMR, and 13C-NMR spectroscopy. The antiproliferative activities of 1 and 2 were tested against MCF-7 (breast) and HT-29 (colon) cancer cells using an MTT assay. 1 showed strong antiproliferative activity against both MCF-7 and HT-29 cancer cells, with IC50 values of 74.6 ± 8.35 and 174 ± 20.28 µg/mL, respectively. In addition, 2 exhibited the maximum antioxidant activity, with an EC50 value of 1029 ± 196.76 µg/mL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10113924
- Volume :
- 38
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bulletin of the Chemical Society of Ethiopia
- Publication Type :
- Academic Journal
- Accession number :
- 177272759
- Full Text :
- https://doi.org/10.4314/bcse.v38i3.5