PREPARATION, SPECTROSCOPIC AND ANTICANCER INVESTIGATIONS OF METAL-DRUG COMPLEXES ASSOCIATED BETWEEN FLUMEQUINE ANTIBIOTIC DRUG WITH LANTHANUM(III), SAMARIUM(III) AND TERBIUM(III) CHLORIDE.

Flumequine ligand (FLQ) metal complexes of the [M(FLQ)2(Cl)(H2O)].nH2O type, where M are (La(III), Sm(III), and Tb(III)) and FLQ is flumequine have been synthesized. The FLQ metal complexes could be prepared using MCl3 : flumequine in stoichiometry of 1:2 in situ bidentate chelation. The characterization of FLQ complexes obtained have been done using elemental analyses (%C, %H and %N), molar conductivity (Λm), infrared spectroscopy (FTIR), electronic spectra (UV-Vis), thermal analysis (TGA), and physicochemical techniques such as X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) measurements at room temperature. Accordingly, these complexes are indicative of an octahedral coordination structure. Flumequine ligand has a bidentate fashion through the oxygen atoms of carbonyl (quinolone) and carboxylic groups. The findings demonstrated the anti-cancer efficacy of these compounds against HepG-2 and MCF-7 cancer cell lines at extremely low doses of up to 58.2 · g/mL. The La(III) complex was shown to have the highest selectivity against cancer cells in comparable with both samarium and terbium(III) complexes. [ABSTRACT FROM AUTHOR]