'Microgravity's dental dilemma: Navigating oral health challenges in space, from effect on bone to therapeutic frontiers – A review'.

For many years, space human factors research has focused on the impact of microgravity on human physiology and the health risks astronauts face during space flights of various durations. Our review paper reveals that microgravity leads to both reversible and non-reversible effects on astronauts' oral health. In addition to oral health concerns, astronauts often experience muscle degeneration during space missions, which is closely tied to bone loss. Despite our knowledge of high bone resorption and rapid mineral and calcium loss in microgravity, the exact underlying mechanisms remain unclear. However, to fully understand these processes and develop effective strategies to counteract the consequences of microgravity, more research is needed. This includes a deeper exploration of how these molecules and other biomarkers work, identification of early mechanotransduction sensors, and a comprehensive understanding of the physiological effects of weightlessness. Current solutions primarily involve administering antioxidants, regular exercise, and appropriate nutrition. Additionally, innovative approaches such as experimental drug therapies using anti -myostatin antibodies and r-irisin have gained attention. Further large-scale, long-term studies are required to understand the effects of microgravity on the oral cavity and prevent its adverse consequences. • Impact of Microgravity on Dental Health: Discuss the physiological changes experienced by astronauts in microgravity environments, including fluid redistribution, decreased mechanical loading, and altered bone metabolism, and their implications for oral health. • Weight-Bearing vs. Non-Weight-Bearing Bones: Examines the relationship between microgravity and bone loss, with a focus on distinguishing its effects on weight-bearing and non-weight-bearing bones. • Comprehensive Impact Assessment: Calls for comprehensive research on how microgravity affects various bones in both animals and humans, including analyses of bone structure, density, and strength. • Bone Loss and Tooth Mobility: Examine how microgravity-induced bone loss affects the integrity of the jawbone, leading to increased tooth mobility and potential dental complications such as loosened crowns, dental implants, or even tooth loss. • Differential Recovery: Investigates how weight-bearing and non-weight-bearing bones recover following bone loss in microgravity conditions and the underlying mechanisms at play. • Addressing Inconsistencies: Highlights the need to resolve inconsistencies in existing literature regarding the influence of microgravity on osteogenic proliferation and differentiation. • Osteocytes and Osteoclasts in Microgravity: Emphasises the importance of understanding the roles of osteocytes and osteoclasts in microgravity-induced bone loss to identify potential therapeutic targets. [ABSTRACT FROM AUTHOR]