Back to Search
Start Over
Trained immunity: General and emerging concepts.
- Source :
-
Immunological Reviews . May2024, Vol. 323 Issue 1, p164-185. 22p. - Publication Year :
- 2024
-
Abstract
- Summary: Over the past decade, compelling evidence has unveiled previously overlooked adaptive characteristics of innate immune cells. Beyond their traditional role in providing short, non‐specific protection against pathogens, innate immune cells can acquire antigen‐agnostic memory, exhibiting increased responsiveness to secondary stimulation. This long‐term de‐facto innate immune memory, also termed trained immunity, is mediated through extensive metabolic rewiring and epigenetic modifications. While the upregulation of trained immunity proves advantageous in countering immune paralysis, its overactivation contributes to the pathogenesis of autoinflammatory and autoimmune disorders. In this review, we present the latest advancements in the field of innate immune memory followed by a description of the fundamental mechanisms underpinning trained immunity generation and different cell types that mediate it. Furthermore, we explore its implications for various diseases and examine current limitations and its potential therapeutic targeting in immune‐related disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOLOGIC memory
*IMMUNITY
*PSYCHONEUROIMMUNOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 01052896
- Volume :
- 323
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunological Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 177322104
- Full Text :
- https://doi.org/10.1111/imr.13326