Photochemical Radical Cascade 6‐endo Cyclization of Dienes with α‐Carbonyl Bromides for the Synthesis of Six‐Membered Benzo‐Fused Lactams.

Comprehensive Summary A novel visible‐light‐induced radical cascade 6‐endo cyclization of dienes (N‐(2‐vinylphenyl)acryl amides) is developed utilizing α‐carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six‐membered benzo‐fused lactam derivatives with chemo‐ and regio‐selectivity and good functional group tolerance. Primary, secondary, and tertiary bromides are well‐compatible with this cascade cyclization reaction. [ABSTRACT FROM AUTHOR]