Assessing the Martini 3 protein model: A review of its path and potential.

Coarse-grained (CG) protein models have become indispensable tools for studying many biological protein details, from conformational dynamics to the organization of protein macro-complexes, and even the interaction of proteins with other molecules. The Martini force field is one of the most widely used CG models for bio-molecular simulations, partly because of the enormous success of its protein model. With the recent release of a new and improved version of the Martini force field – Martini 3 – a new iteration of its protein model was also made available. The Martini 3 protein force field is an evolution of its Martini 2 counterpart, aimed at improving many of the shortcomings that had been previously identified. In this mini-review, we first provide a general overview of the model and then focus on the successful advances made in the short time since its release, many of which would not have been possible before. Furthermore, we discuss reported limitations, potential directions for model improvement and comment on what the likely future development and application avenues are. • Computational methods like Martini play key roles in deciphering protein function. • The Martini 3 protein model improves on past iterations, addressing many shortcomings. • Despite success, soon after release, reports note hindrances to its applicability. • We explore improvement directions and discuss future development and applications. [ABSTRACT FROM AUTHOR]