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Comparative evaluation of biomechanical changes and aberration profile following accelerated collagen cross-linking using hypo-osmolar and iso-osmolar riboflavin: A prospective study.
- Source :
-
Indian Journal of Ophthalmology . May2024, Vol. 72 Issue 5, p712-717. 6p. - Publication Year :
- 2024
-
Abstract
- To compare the changes encountered in corneal biomechanics and aberration profile following accelerated corneal collagen cross-linking (CXL) using hypo-osmolar and iso-osmolar riboflavin in corneal thicknesses of <400 and >400 microns, respectively. Methods: This is a prospective, interventional, comparative study involving 100 eyes of 75 patients with progressive keratoconus. Eyes were divided into two groups based on corneal thickness: group 1 included eyes with a corneal thickness of <400 microns who underwent hypo-osmolar CXL, and group 2 included eyes with a corneal thickness of >400 microns who underwent iso-osmolar CXL. Corneal biomechanical and aberration profiles were evaluated and compared between groups. Results: In group 1, all higher-order aberrations (HOA) except secondary astigmatism significantly decreased from baseline; however, in group 2, only coma and trefoil decreased. The corneal resistance factor and corneal hysteresis significantly improved in both groups, which was significantly greater in group 2 than in group 1. The change in inverse radius, deformation amplitude, and tomographic biomechanical index was significantly improved in group 2 as compared to group 1. Conclusion: Improvement in corrected distance visual acuity and decrease in HOA were significantly better in the hypo-osmolar CXL group; however, the improvement in biomechanical strength of the cornea was significantly better in the iso-osmolar group. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORNEAL cross-linking
*VITAMIN B2
*LONGITUDINAL method
*COLLAGEN
*VISUAL acuity
Subjects
Details
- Language :
- English
- ISSN :
- 03014738
- Volume :
- 72
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 177444436
- Full Text :
- https://doi.org/10.4103/IJO.IJO_1387_23