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Doxycycline inhibits neurotropic enterovirus proliferation in vitro.
- Source :
-
Virus Research . Jul2024, Vol. 345, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- • Doxycycline inhibits the replication of neurotropic enteroviruses in vitro. • Treatment one hour post-infection inhibited viral replication. • The inhibitory mechanism is at the post-viral entry stage. Human enteroviruses (EVs) represent a global public health concern due to their association with a range of serious pediatric illnesses. Despite the high morbidity and mortality exerted by EVs, no broad-spectrum antivirals are currently available. Herein, we presented evidence that doxycycline can inhibit in vitro replication of various neurotropic EVs, including enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and coxsackievirus (CV)-A6, in a dose-dependent manner. Further investigations indicated that the drug primarily acted at the post-entry stage of virus infection in vitro, with inhibitory effects reaching up to 89 % for EV-A71 when administered two hours post-infection. These findings provide valuable insights for the development of antiviral drugs against EV infections. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01681702
- Volume :
- 345
- Database :
- Academic Search Index
- Journal :
- Virus Research
- Publication Type :
- Academic Journal
- Accession number :
- 177455678
- Full Text :
- https://doi.org/10.1016/j.virusres.2024.199388