Radiation Safety Assessment in Prostate Cancer Treatment: A Predictive Approach for I-125 Brachytherapy.

Simple Summary: External dose rate measurements for I-125 permanent radioactive source implantation brachytherapy for prostate cancer requires standardized external dose rate measurements and radiation safety procedures. We developed predictive models for external dose rates to ensure compliance with radiation safety guidelines. We used Monte Carlo simulation and experimental measurements to construct an external dose rate model. The model's accuracy was validated against external dose rate measurements from clinical patients. This model facilitates the calculation and minimization of family members' radiation dose, aiding in the development of personalized radiation protection strategies. This study uses Monte Carlo simulation and experimental measurements to develop a predictive model for estimating the external dose rate associated with permanent radioactive source implantation in prostate cancer patients. The objective is to estimate the accuracy of the patient's external dose rate measurement. First, I-125 radioactive sources were implanted into Mylar window water phantoms to simulate the permanent implantation of these sources in patients. Water phantom experimental measurement was combined with Monte Carlo simulation to develop predictive equations, whose performance was verified against external clinical data. The model's accuracy in predicting the external dose rate in patients with permanently implanted I-125 radioactive sources was high (R2 = 0.999). A comparative analysis of the experimental measurements and the Monte Carlo simulations revealed that the maximum discrepancy between the measured and calculated values for the water phantom was less than 5.00%. The model is practical for radiation safety assessments, enabling the evaluation of radiation exposure risks to individuals around patients with permanently implanted I-125 radioactive sources. [ABSTRACT FROM AUTHOR]