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Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?
- Source :
-
Viruses (1999-4915) . May2024, Vol. 16 Issue 5, p666. 15p. - Publication Year :
- 2024
-
Abstract
- Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*DRUG target
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 16
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 177496129
- Full Text :
- https://doi.org/10.3390/v16050666