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Facile access to C-substituted piperazin-2-ones and mianserin derivative enabled by chemoselective carbene insertion and cyclization cascade.
- Source :
-
Chemical Communications . 6/4/2024, Vol. 60 Issue 44, p5691-5694. 4p. - Publication Year :
- 2024
-
Abstract
- The chemoselective N-H insertion of unsymmetrical diamines into carbene is a longstanding challenge. A simple copper-catalyzed strategy for synthesizing C-substituted piperazinones is described, employing easily accessible diazo compounds and 1,2-diamines. The reaction proceeded via chemo-selective carbene insertion at the comparatively less nucleophilic amine, followed by instantaneous cyclization. The protocol was further extended to access NH-free piperazinone, and the synthesis of a Mianserin derivative. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*DIAZO compounds
*DIAMINES
*CARBENES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 44
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 177548830
- Full Text :
- https://doi.org/10.1039/d4cc00959b