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Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study.
- Source :
-
European Journal of Nutrition . Jun2024, Vol. 63 Issue 4, p1329-1338. 10p. - Publication Year :
- 2024
-
Abstract
- Purpose : The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. Methods: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. Results: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. Conclusion: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of pantothenic acid
*THERAPEUTIC use of folic acid
*TYPE 1 diabetes
*RISK assessment
*FOOD consumption
*RESEARCH funding
*VITAMIN B1
*SCIENTIFIC observation
*VITAMIN B2
*ISLANDS of Langerhans
*LONGITUDINAL method
*VITAMIN B6
*CONFIDENCE intervals
*DIET
*DISEASE progression
*NIACIN
*PROPORTIONAL hazards models
*DISEASE risk factors
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 63
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 177559862
- Full Text :
- https://doi.org/10.1007/s00394-024-03346-6