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Microfluidic-based preparation of PLGA microspheres facilitating peptide sustained-release.
- Source :
-
Materials Letters . Aug2024, Vol. 368, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Exenatide −loaded PLGA microspheres were prepared via the water/oil/water (W/O/W) emulsion method using the microfluidic device. [Display omitted] • Ext-loaded PLGA microspheres with good monodispersity were prepared using the microfluidic device. • The critical quality attributes of peptide-loaded microspheres and their influencing factors were systematically studied. • The designed microfluidic device had the capability to operate in a highly parallel manner. It is challenging for the manufacturing of microspheres loaded with peptide due to the complicated preparation process and the issue of burst release. In this construct, a microfluidic flow-focusing device is developed to prepare and optimize poly (lactic- co -glycolic acid) (PLGA) Exenatide −loaded microspheres. Surfactants was added to greatly improve the stability of the emulsion, leading to increase drug loading capacity. By increasing the particle size of the drug-loaded microspheres to 30 μm, the burst release was significantly reduced. Additionally, multi-channel droplet microfluidic devices are prepared with the capability to achieve a 100-fold increase in throughput, which could achieve a production rate of 2 g per hour. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICROSPHERES
*PEPTIDES
*MICROFLUIDIC devices
*POLYMERIC composites
Subjects
Details
- Language :
- English
- ISSN :
- 0167577X
- Volume :
- 368
- Database :
- Academic Search Index
- Journal :
- Materials Letters
- Publication Type :
- Academic Journal
- Accession number :
- 177599202
- Full Text :
- https://doi.org/10.1016/j.matlet.2024.136675