Preparation of woven scaffolds with porous structure and piezoelectric stimulation capability for osteoblast regeneration.

Bone tissue generates many biological signals during self-repair and regeneration, of which the transmission of electrical signals is critical to the success of bone repair. Therefore, in this study, barium titanate/hydroxyapatite(BT/HA) composite nanoparticles were synthesized using a hydrothermal method at 170°C, and BT/HA scaffolds with piezoelectric stimulation were prepared by blending them with sodium alginate in combination with two-dimensional braided tubes. The scaffolds were distributed with a pore size of 30–100 μm, a porosity of 60-70 %, a swelling rate of more than 300 %, and output voltages and currents of about 800 mV and 2.4 μA. The degradation rate reached 3.59 % after 21 days, and in vitro cell cultures confirmed that polarised scaffolds could further promote cell proliferation and differentiation. The cell survival rate on the polarised scaffold was 174.77 %. This study provides a new idea for the combination of piezoelectric materials and woven structures, which can be potentially applied to the field of bone repair. [Display omitted] • BT/HA nanocomposites synthesized by hydrothermal method. • Braided structures were used as scaffold carriers with high porosity and inter-crosslinked pore structures to provide a suitable environment for cell adhesion and growth. • The prepared BT/HA scaffolds have the ability of piezoelectric stimulation, which can output a voltage of about 800 mV and a current of 2.4 μA. • The BT/HA scaffold has good biodegradability and can degrade 3.59 % of its own weight within 21 days. • The cell survival rate on the scaffold was 174.77 %. In vitro cell culture confirmed that the enhanced electrical output further promoted cell proliferation and differentiation. [ABSTRACT FROM AUTHOR]