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Integrated convolution and self-attention for improving peptide toxicity prediction.

Authors :
Jiao, Shihu
Ye, Xiucai
Sakurai, Tetsuya
Zou, Quan
Liu, Ruijun
Source :
Bioinformatics. May2024, Vol. 40 Issue 5, p1-9. 9p.
Publication Year :
2024

Abstract

Motivation Peptides are promising agents for the treatment of a variety of diseases due to their specificity and efficacy. However, the development of peptide-based drugs is often hindered by the potential toxicity of peptides, which poses a significant barrier to their clinical application. Traditional experimental methods for evaluating peptide toxicity are time-consuming and costly, making the development process inefficient. Therefore, there is an urgent need for computational tools specifically designed to predict peptide toxicity accurately and rapidly, facilitating the identification of safe peptide candidates for drug development. Results We provide here a novel computational approach, CAPTP, which leverages the power of convolutional and self-attention to enhance the prediction of peptide toxicity from amino acid sequences. CAPTP demonstrates outstanding performance, achieving a Matthews correlation coefficient of approximately 0.82 in both cross-validation settings and on independent test datasets. This performance surpasses that of existing state-of-the-art peptide toxicity predictors. Importantly, CAPTP maintains its robustness and generalizability even when dealing with data imbalances. Further analysis by CAPTP reveals that certain sequential patterns, particularly in the head and central regions of peptides, are crucial in determining their toxicity. This insight can significantly inform and guide the design of safer peptide drugs. Availability and implementation The source code for CAPTP is freely available at https://github.com/jiaoshihu/CAPTP. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13674803
Volume :
40
Issue :
5
Database :
Academic Search Index
Journal :
Bioinformatics
Publication Type :
Academic Journal
Accession number :
177611687
Full Text :
https://doi.org/10.1093/bioinformatics/btae297