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Multiple drugs: Various toxicities and lack of efficacy.
- Source :
-
Reactions Weekly . Apr2024, Vol. 2003 Issue 1, p640-640. 1p. - Publication Year :
- 2024
-
Abstract
- A 45-year-old woman experienced myelodysplasia, trilinear cytopenia, and cytokine release syndrome while being treated with tisagenlecleucel for relapsed/refractory diffuse large B cells lymphoma. She also showed lack of efficacy during treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, bendamustine, methotrexate, and erythropoietin for low-grade lymphoma or anemia. The woman underwent autologous stem cell transplantation and received CAR-T therapy with tisagenlecleucel infusion. She experienced complications such as cytokine release syndrome and grade 4 trilinear cytopenia, but eventually achieved complete remission of the lymphoma. However, she developed myelodysplasia secondary to tisagenlecleucel and experienced persistent cytopenia, although it improved over time. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 01149954
- Volume :
- 2003
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Reactions Weekly
- Publication Type :
- Periodical
- Accession number :
- 177624474
- Full Text :
- https://doi.org/10.1007/s40278-024-56471-6