Synthesis of 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3H)-thione] and Study of Its Anti-Inflammatory Activity.

5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-thiadiazole-2(3H)-thione] was synthesized by oxidative condensation in the presence of chloride ions. The structure of the resulting compound was identified by an x-ray crystal structure analysis, for which the crystallographic data were obtained. The anti-inflammatory activity of the synthesized disulfide was studied for the first time in a carrageenan edema model. 5,5′-(Disulfanediyl)bis[3-phenyl-1,3,4-diazole-2(3H)-thione] was shown to have anti-inflammatory and antiexudative activity at doses of 10 and 20 mg/kg. Its effect was close to that of the drug Nimesil. [ABSTRACT FROM AUTHOR]