Immune repertoire sequencing for precision diagnosis in kidney transplantation.

This article discusses the use of immune repertoire sequencing as a non-invasive and precise diagnostic method for kidney transplant rejection. The study enrolled 10 recipients with ambiguous diagnoses of transplant kidney dysfunction and used immune repertoire sequencing to classify patients into rejection and non-rejection categories. The sequencing results largely matched biopsy pathological results, with major clone expansions corresponding to rejection types. The study also demonstrated the potential of immune repertoire sequencing in monitoring treatment effectiveness and diagnosing refractory rejection. However, further research is needed to analyze patterns in immune repertoire changes associated with viral infections or calcineurin inhibitors toxicity. [Extracted from the article]