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Protective Effects of β-Blockers on Bone in Older Adults with Dementia.
- Source :
-
Calcified Tissue International . Jul2024, Vol. 115 Issue 1, p14-22. 9p. - Publication Year :
- 2024
-
Abstract
- Increased β-adrenergic receptor activity has been hypothesized to cause bone loss in those with dementia. We investigated the effect of long-term β-blocker use on rate of bone loss in older adults with dementia. We used a linear mixed-effects model to estimate the relationship between long-term β-blocker use and rate of bone loss in participants from the Health Aging and Body Composition study. Records of 1198 participants were analyzed, 44.7% were men. Among the men, 25.2% had dementia and 20.2% were on β-blockers, while in the women, 22.5% had dementia and 16.6% received β-blockers. In the 135 men with dementia, 23 were taking β-blockers, while 15 of 149 women with dementia were using β-blockers. In men with dementia, β-blocker users had 0.00491 g/cm2 less bone mineral density (BMD) loss per year at the femoral neck (i.e., 0.63% less loss per year) than non-users (p < 0.05). No differences were detected in women with or without dementia and men without dementia. β-blockers may be protective by slowing down bone loss in older men with dementia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OLDER people
*DEMENTIA
*BONE density
*FEMUR neck
*OLDER men
*BODY composition
Subjects
Details
- Language :
- English
- ISSN :
- 0171967X
- Volume :
- 115
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Calcified Tissue International
- Publication Type :
- Academic Journal
- Accession number :
- 177673852
- Full Text :
- https://doi.org/10.1007/s00223-024-01221-4