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Rh2(esp)2-catalyzed three-component reaction of a diazo compound, alkyl azide and allylboronate for the synthesis of homoallylic amine derivatives.
- Source :
-
New Journal of Chemistry . 6/14/2024, Vol. 48 Issue 22, p9885-9889. 5p. - Publication Year :
- 2024
-
Abstract
- The three-component reaction of a diazo compound, azide and allylboronate was explored, and Rh2(esp)2 was utilized as the optimal catalyst. A series of α-amino esters were efficiently produced from the ethyl diazoacetate in 57–84% yields, and excellent diastereoselectivities were observed with the reaction employing (E)-allylboronate as the alkylation reagent. The α-amino ketone or homoallylic amine could also be prepared by using α-diazo ketone or trimethylsilyl diazomethane in acceptable yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINE derivatives
*KETONES
*DIAZO compounds
*DIAZOMETHANE
*ESTERS
*ALKYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 48
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 177682178
- Full Text :
- https://doi.org/10.1039/d4nj01189a