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Evaluation of adropin, fibroblast growth factor-1 (FGF-1), and Toll-like receptor-1 (TLR1) biomarkers in patients with inflammatory bowel disease: gene expression of TNF-α as a marker of disease severity.
- Source :
-
Egyptian Journal of Medical Human Genetics . 6/5/2024, Vol. 25 Issue 1, p1-7. 7p. - Publication Year :
- 2024
-
Abstract
- Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of unknown etiology and unpredictable course. The aim of the work was to assess the levels of adropin, fibroblast growth factor-1 (FGF-1), and Toll-like receptor-1 (TLR1) biomarkers in IBD patients compared to controls and evaluate the gene expression of TNF-α as a marker of disease severity. Methods: Adropin, fasting serum FGF-1 levels, TLR1, and TNF-α were measured in 60 IBD patients. They were also compared with 58 healthy controls matching age and gender. Moreover, the blood cells cDNA copy number of TNF-α were determined as a marker of severity. Results: Adropin and TLR1 levels were significantly lower in patients than controls. FGF-1 was reduced but not statistically significant. The expression of TNF-α gene in the IBD patients was significantly increased (42%) in comparison with control samples (P < 0.001). Conclusions: Adropin, IGF-I, and Toll-like receptor-1 biomarkers may have a role in the intricate pathophysiology of IBD and may possibly operate as predictors of disease activity. Thus, they may be therapeutic targets for IBD. Moreover, the expression of TNF-α gene can be used as a marker of severity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11108630
- Volume :
- 25
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Egyptian Journal of Medical Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 177714698
- Full Text :
- https://doi.org/10.1186/s43042-024-00533-2