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An Alternative Cascade for the Selective Methylation of Catechols and Tetrahydroisoquinolines by O‐Methyltransferases.
- Source :
-
ChemCatChem . May2024, p1. 7p. 6 Illustrations, 1 Chart. - Publication Year :
- 2024
-
Abstract
- Methyltransferases are gaining traction as a method to achieve greener and regioselective methylations of a wide array of substrates. In this work, a halide methyltransferase biomethylation cascade was successfully adapted with the incorporation of a methionine adenosyltransferase to generate the <italic>S</italic>‐adenosyl‐L‐methionine (SAM) methylation cofactor <italic>in situ</italic> from less costly ATP and L‐methionine, instead of directly adding SAM to start the cascade. Furthermore, this cascade was applied to achieve novel catechol and tetrahydroisoquinoline methylations with the <italic>O</italic>‐methyltransferases <italic>Rn</italic>COMT, <italic>Mx</italic>SafC and <italic>Np</italic>N4OMT with high conversions and regioselectivities. In addition, the cascade was successfully trialled with the less toxic methyl group donor, methyl tosylate. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18673880
- Database :
- Academic Search Index
- Journal :
- ChemCatChem
- Publication Type :
- Academic Journal
- Accession number :
- 177736235
- Full Text :
- https://doi.org/10.1002/cctc.202400492