Anti-MRSA Pyrone Derivative Products Isolated from Plant-Derived Fungus Aspergillus niger Pas67.

A new pyrone derivative 11-hydroxypyrophen (1), together with pyrophen (2) and six naphtho-γ-pyrones (3–8), were obtained from the culture extract of Aspergillus niger Pas67. All isolated compounds were evaluated for their antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 4 and 8 showed significant antibacterial activity against MRSA with minimum inhibitory concentration values (MICs) of 25 and 16 μg/mL, while compounds 1 and 2 did not display anti-MRSA activity. [ABSTRACT FROM AUTHOR]