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Strategies for inducing and validating zinc deficiency and zinc repletion.
- Source :
-
American Journal of Physiology: Heart & Circulatory Physiology . Jun2024, Vol. 326 Issue 6, pH1396-H1401. 6p. - Publication Year :
- 2024
-
Abstract
- Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases. NEW & NOTEWORTHY: This methods paper details dietary approaches to alter zinc homeostasis in rodents and qualitative and quantitative methods to ensure the zinc status of experimental animals. The outlined accessible and cost-effective protocol will elevate scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of a multitude of health conditions and diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ZINC
*LABORATORY animals
*DISEASE progression
*HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 03636135
- Volume :
- 326
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology: Heart & Circulatory Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 177746193
- Full Text :
- https://doi.org/10.1152/ajpheart.00025.2024