Sensitive surface plasmon resonance biosensor by optimized carboxylate functionalized carbon nanotubes/chitosan for amlodipine detecting.

The adoption of biophotonic sensing technologies holds significant promise for application in health care and biomedical industries in all aspects of human life. Then, this piece of writing employs the powerful effective medium theory and FDTD simulation to anticipate the most favorable state and plasmonic attributes of a magnificent nanocomposite, comprising carboxylate functionalized carbon nanotubes and chitosan (CS). Furthermore, it thoroughly explores the exhibited surface plasmon resonance behaviors of this composite versus the quantity of CS variation. Subsequently, enlightening simulations are conducted on the nanocomposite with a delicate layer and a modified golden structure integrating as a composite. The intricate simulations eventually unveil an optimal combination to pave the way for crafting an exceptional specific biosensor that far surpasses its counterpart as a mere Au thin layer in terms of excellence. The proposed biosensor demonstrated linear behavior across a wide range from 0.01 μM to 150 μM and achieved a detection limit of 10 nM, with a sensitivity of 134◦RIU−1. [Display omitted] • Sensor chip modification with carboxylate functionalized carbon nanotubes (CCNT) and chitosan (CS) increased its sensitivity. • Carboxylate functionalized carbon nanotube- Chitosan thin film attracted Amlodipine causing refractive index change. • We emphasized to first optimize the desired composite with mathematical methods and then proceed to manufacture it. • The laboratory results were obtained in accordance with the simulation results. • We used real samples in testing the proposed sensor. [ABSTRACT FROM AUTHOR]