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Immunohistochemical analysis of PDGFR-α for wound age determination.
- Source :
-
International Journal of Legal Medicine . Jul2024, Vol. 138 Issue 4, p1351-1356. 6p. - Publication Year :
- 2024
-
Abstract
- Immunohistochemical analysis of platelet-derived growth factor receptor-α (PDGFR-α) was performed on human skin wounds obtained from forensic autopsy cases. Thirty human skin wounds were collected at different post-infliction intervals as follows: Group I, 4 h to 3 days (n = 16); Group II, 4 to 7 days (n = 7); Group III, 9 to 10 days (n = 3); and Group IV, 14 to 20 days (n = 4). Immunopositive reactions for PDGFR-α were not observed in the uninjured human skin specimens. In a semi-quantitative morphometrical analysis, the number of PDGFR-α-positive cells was observed increased in Group II, with the average number of PDGFR-α-positive cells being the highest in Group II. Additionally, in Group II, all specimens showed PDGFR-α-positive cells, with an average number of > 200 cells in five fields of view, suggesting a wound age of 4 to 7 days. Taken together, the immunohistochemical detection of PDGFR-α in human skin wounds can be a useful tool for wound age determination. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOHISTOCHEMISTRY
*PLATELET-derived growth factor
*SKIN injuries
Subjects
Details
- Language :
- English
- ISSN :
- 09379827
- Volume :
- 138
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Legal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 177777851
- Full Text :
- https://doi.org/10.1007/s00414-024-03208-0