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Organocatalyzed, Three‐Component Construction of Cyanopyrazoles Using Diazoacetonitrile.
- Source :
-
Advanced Synthesis & Catalysis . 6/10/2024, Vol. 366 Issue 11, p2551-2556. 6p. - Publication Year :
- 2024
-
Abstract
- An organocatalyzed three‐component protocol using diazoacetonitrile to access a wide range of cyanopyrazole derivatives is reported here. This strategy, which proceeds through a piperidine‐catalyzed Knoevenagel condensation/formal [3+2] cycloaddition/dehydrocyanation sequence, provides an efficient route to construct dicyanopyrazoles from aldehydes, malononitrile, and diazoacetonitrile regioselectively. Interestingly, by engaging cyanoacetate and cyanoacetamide in this protocol, we could achieve cyanopyrazole esters and carboxamides. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 177798338
- Full Text :
- https://doi.org/10.1002/adsc.202400207