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Screening of potential α-glucosidase inhibitors from <italic>astragalus membranaceus</italic> by affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS method.
- Source :
-
Journal of Asian Natural Products Research . Jun2024, p1-10. 10p. 4 Illustrations, 2 Charts. - Publication Year :
- 2024
-
Abstract
- Abstract<italic>Astragalus membranaceus</italic> is a traditional Chinese medicine with multiple pharmacological activities. Modern pharmacological research has found that <italic>Astragalus membranaceus</italic> extract has an inhibitory effect on α-glucosidase, however, which component can inhibit the activity of α-glucosidase and its degree of inhibition are unknown. To address this issue, this study used affinity ultrafiltration screening combined with UPLC-ESI-Orbitrap-MS technology to screen α-glucosidase inhibitors in <italic>Astragalus membranaceus</italic>. Using affinity ultrafiltration technology, we obtained the active components, and using UPLC-ESI-Orbitrap-MS technology, we quickly analyzed and identified them. As a result, a total of 8 ingredients were selected as α-glucosidase inhibitors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 177828686
- Full Text :
- https://doi.org/10.1080/10286020.2024.2366007