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Regulated vascular smooth muscle cell death in vascular diseases.

Authors :
Yin, Zheng
Zhang, Jishou
Shen, Zican
Qin, Juan‐Juan
Wan, Jun
Wang, Menglong
Source :
Cell Proliferation. Jun2024, p1. 19p. 9 Illustrations, 1 Chart.
Publication Year :
2024

Abstract

Regulated cell death (RCD) is a complex process that involves several cell types and plays a crucial role in vascular diseases. Vascular smooth muscle cells (VSMCs) are the predominant elements of the medial layer of blood vessels, and their regulated death contributes to the pathogenesis of vascular diseases. The types of regulated VSMC death include apoptosis, necroptosis, pyroptosis, ferroptosis, parthanatos, and autophagy‐dependent cell death (ADCD). In this review, we summarize the current evidence of regulated VSMC death pathways in major vascular diseases, such as atherosclerosis, vascular calcification, aortic aneurysm and dissection, hypertension, pulmonary arterial hypertension, neointimal hyperplasia, and inherited vascular diseases. All forms of RCD constitute a single, coordinated cell death system in which one pathway can compensate for another during disease progression. Pharmacologically targeting RCD pathways has potential for slowing and reversing disease progression, but challenges remain. A better understanding of the role of regulated VSMC death in vascular diseases and the underlying mechanisms may lead to novel pharmacological developments and help clinicians address the residual cardiovascular risk in patients with cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09607722
Database :
Academic Search Index
Journal :
Cell Proliferation
Publication Type :
Academic Journal
Accession number :
177830168
Full Text :
https://doi.org/10.1111/cpr.13688