Research progress on GPX4 targeted compounds.

Blocking the System X c −_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein, including inhibitors, activators, small molecule degraders, chimeric degraders, and the application of combination therapies with other drugs, aiming to promote further research on the target and related diseases. [Display omitted] • This article provides an overview and research progress of the small molecules targeting GPX4. • The characteristics, advantages and limitations of these compounds are summarized. • The application of combination therapies with other drugs are also mentioned. [ABSTRACT FROM AUTHOR]