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Minimal impact of low-density lipoprotein apheresis on vancomycin serum concentration: A case report.

Authors :
Hiyama, Yoko
Tomita, Takashi
Matsuo, Hiroaki
Source :
Journal of Infection & Chemotherapy (Elsevier Inc.). Aug2024, Vol. 30 Issue 8, p812-814. 3p.
Publication Year :
2024

Abstract

Low-density lipoprotein apheresis (LDL-A) is a blood purification therapy used to treat refractory ulcers in patients with arteriosclerosis obliterans. We describe a case of vancomycin treatment in a patient undergoing maintenance hemodialysis and LDL-A therapy and assess its impact on serum vancomycin concentration. The patient underwent LDL-A twice a week (Mondays and Fridays) and maintenance dialysis three times a week (Tuesdays, Thursdays, and Saturdays) for diabetic nephropathy associated with type 1 diabetes mellitus. Following the wound culture results, vancomycin was initiated with a 1.75 g administration post-dialysis. Serum vancomycin levels before and after LDL-A, measured on the subsequent day, exhibited only slight fluctuations within the intermeasurement variability range. Despite continuing vancomycin administration at the standard dose in patients undergoing hemodialysis, the serum concentration remained consistent, suggesting a minimal impact of LDL-A on vancomycin pharmacokinetics. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*TYPE 1 diabetes
*VANCOMYCIN

Details

Language :
English
ISSN :
1341321X
Volume :
30
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Infection & Chemotherapy (Elsevier Inc.)
Publication Type :
Academic Journal
Accession number :
177870072
Full Text :
https://doi.org/10.1016/j.jiac.2024.01.018