Back to Search
Start Over
Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques.
- Source :
-
Journal of Infectious Diseases . 6/15/2024, Vol. 229 Issue 6, p1791-1795. 5p. - Publication Year :
- 2024
-
Abstract
- Vaginal inserts that can be used on demand before or after sex may be a desirable human immunodeficiency virus (HIV) prevention option for women. We recently showed that inserts containing tenofovir alafenamide fumarate (TAF, 20 mg) and elvitegravir (EVG, 16 mg) were highly protective against repeated simian/human immunodeficiency virus (SHIV) vaginal exposures when administered to macaques 4 hours before or after virus exposure (93% and 100%, respectively). Here, we show in the same macaque model that insert application 8 hours or 24 hours after exposure maintains high efficacy (94.4% and 77.2%, respectively). These data extend the protective window by TAF/EVG inserts and inform their clinical development for on-demand prophylaxis in women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*MACAQUES
*HIV
*TENOFOVIR
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 229
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 177905190
- Full Text :
- https://doi.org/10.1093/infdis/jiad599