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Electrochemical direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines.
- Source :
-
Green Chemistry . 6/21/2024, Vol. 26 Issue 12, p7419-7423. 5p. - Publication Year :
- 2024
-
Abstract
- We have developed a straightforward electrochemical protocol for direct α-amidation and α-pyrazolation of N-alkoxy- and N-aryloxycarbonyl pyrrolidines with amides or pyrazoles. Unlike previously reported methods, this protocol does not require pre-prepared amidation reagents, thereby shortening the synthesis route and boosting atom economy. Various functional groups are tolerated, and the reaction proceeds at room temperature in only 2.5 h without assistance from chemical oxidants or catalysts. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMIDATION
*FUNCTIONAL groups
*PYRAZOLES
*AMIDES
*OXIDIZING agents
*CATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 26
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 177927893
- Full Text :
- https://doi.org/10.1039/d4gc01689k