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Evaluation of the risk of developing hepatocellular carcinoma in chronic Hepatitis C patients receiving antiviral treatment.

Authors :
Sargsyan, Sona
Magdesieva, Hripsime
Navoyan, Tsoghik
Mkhitaryan, Aregnaz
Atoyan, Lusine
Sargsyan, Violeta
Harutyunyan, Hayk
Azatyan, Vahe
Minasyan, Armine
Gyulazyan, Naira
Source :
Journal of Infection in Developing Countries. May2024, Vol. 18 Issue 5, p794-801. 8p.
Publication Year :
2024

Abstract

Introduction: Chronic HC leads to the development of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The treatment of chronic HC with DAAs reduces mortality from LC and HCC. The study aimed to investigate the serological markers specific to HCC (PIVKA-II and AFP) in patients with chronic HC before and after DAA treatment. Methodology: The study involved 35 HCV patients (mean age: 56.23 ± 1.45) divided into two groups. Group 1 included 15 HCV + HCC patients and Group 2 included 20 HCV non-HCC patients. Results: At the end of treatment all the patients were HCV RNA negative. Three months after the end of antiviral treatment, HCV RNA was undetectable in all patients, while a complete biochemical and virological response was observed in 66.7% of HCV + HCC patients and 85.0% of HCV non-HCC patients. PIVKA-II levels before the initiation of antiviral treatment were high in all patients. At the end of the treatment, in the HCV non-HCC group, normalization of PIVKA-II levels was observed only in 20.0% cases, and in 60.0% of cases 3 months after the treatment. Meanwhile, in patients with HCC and chronic HCV, PIVKA-II levels were within the normal range 3 months after treatment in only 13.3% of patients. Conclusions: It is necessary to monitor HCV patients with cirrhosis (F4) and severe fibrosis (F3) without HCC, who have high PIVKA-II and AFP levels and/or ALT activity despite obtaining sustained virologic response 3 months after treatment with DAAs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20366590
Volume :
18
Issue :
5
Database :
Academic Search Index
Journal :
Journal of Infection in Developing Countries
Publication Type :
Academic Journal
Accession number :
177932274
Full Text :
https://doi.org/10.3855/jidc.18410