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Assessment of Serum Interleukin-27 and Mean Platelet Volume in Late-Onset Neonatal Sepsis.
- Source :
-
American Journal of Perinatology . Jul2024, Vol. 41 Issue 9, p1232-1237. 6p. - Publication Year :
- 2024
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Abstract
- Objective Late-onset sepsis (LOS) is a substantial contributor to morbidity and mortality among neonates. The use of nonculture-based tools for early diagnosis is an area of active investigation. Therefore, we aimed to evaluate the diagnostic value of serum interleukin-27 (IL-27) and mean platelet volume (MPV) in full-term neonates with LOS. Study Design In this single-center, cross-sectional study, 90 full-term newborns were assigned to two equal-matched groups as follows: (1) culture-proven sepsis and (2) control groups. Clinical data and laboratory findings as complete blood pictures, including MPV, highly sensitive C-reactive protein, and blood culture results, were recorded. Moreover, IL-27 levels were measured using enzyme-linked immunosorbent assay. Results IL-27 levels (median = 4,364 pg/mL) and MPV (mean = 12.02 ± 1.54 FL) were significantly higher in the culture-proven sepsis group than in the control group (p < 0.001). For IL-27, the optimum cut-off value for the diagnosis of LOS was 283.8 pg/mL with sensitivity and specificity of 97.8 and 100%, respectively. For MPV, the optimum cut-off value was 11.6 FL, with diagnostic sensitivity and specificity of 77.8 and 97.8%, respectively. Conclusion IL-27 and MPV are promising markers for the diagnosis of LOS in full-term neonates. The diagnostic performance of IL-27 was superior to MPV. Key Points Late-onset neonatal sepsis diagnosis is time consuming. Nonculture-based rapid diagnostic tests are much needed. IL-27 is superior in LOS diagnosis to MPV. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CROSS-sectional method
*BLOOD
*STATISTICAL power analysis
*ACADEMIC medical centers
*T-test (Statistics)
*DATA analysis
*RECEIVER operating characteristic curves
*GRAM-positive bacterial infections
*STAPHYLOCOCCAL diseases
*ACINETOBACTER infections
*PLATELET count
*BLOOD collection
*ENZYME-linked immunosorbent assay
*NEONATAL intensive care units
*KRUSKAL-Wallis Test
*HEMOGLOBINS
*NEUTROPHILS
*MEAN platelet volume
*DESCRIPTIVE statistics
*NEONATAL intensive care
*BLOOD cell count
*MANN Whitney U Test
*CHI-squared test
*METHICILLIN-resistant staphylococcus aureus
*SERUM
*CELL culture
*DURATION of pregnancy
*KLEBSIELLA infections
*PSEUDOMONAS diseases
*CASE-control method
*URBAN hospitals
*STATISTICS
*DATA analysis software
*COMPARATIVE studies
*GRAM-negative bacterial diseases
*CANDIDIASIS
*INTERLEUKINS
*NEONATAL sepsis
*DELAYED onset of disease
*C-reactive protein
*SENSITIVITY & specificity (Statistics)
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 07351631
- Volume :
- 41
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- American Journal of Perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 177943493
- Full Text :
- https://doi.org/10.1055/s-0042-1748165