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Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors.
- Source :
-
Journal of the American Chemical Society . 7/27/2005, Vol. 127 Issue 29, p10130-10131. 2p. - Publication Year :
- 2005
-
Abstract
- This article presents a structure-based design of potent non-peptide MDM2 oncoprotein inhibitors. It is believed that the p53 tumor suppressor plays a central role in controlling cell cycle progression and apoptosis, and is an attractive cancer therapeutic target because its tumor suppressor activity can be stimulated to eradicate tumor cells. A new approach to stimulation of the activity of p53 is through blocking its interaction with the MDM2 oncoprotein, an endogenous cellular inhibitor of p53, using non-peptide small-molecule MDM2 inhibitors.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 127
- Issue :
- 29
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 17797794
- Full Text :
- https://doi.org/10.1021/ja051147z